2D 3D
	ID	DDInter1447
	Drug Type	small molecule
	Molecular Formula	C10H15N
	Molecular Weight	149.233
	CAS Number	122-09-8
	Description	Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.[A174370] Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential).[A174367] Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to obtain the desired effect.[A174373]
	ATC Classification	A08AA01
IUPAC Name	2-methyl-1-phenylpropan-2-amine
InChI	DHHVAGZRUROJKS-UHFFFAOYSA-N
Canonical SMILES	CC(C)(N)CC1=CC=CC=C1
Useful Links	DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC