Basic Information
ID DDInter1362
Drug Type small molecule
Molecular Formula C11H12N2O3
Molecular Weight 220.225
CAS Number 4350-09-8
Description 5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in the United Kingdom, United States and Canada as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, and is also marketed in many European countries for the indication of major depression under trade names like Cincofarm, Levothym, Levotonine, Oxyfan, Telesol, Tript-OH, and Triptum. Several double-blind placebo-controlled clinical trials have demonstrated the effectiveness of 5-HTP in the treatment of depression, though a lack of high quality studies has been noted. More study is needed to determine efficacy in treating depression.
ATC Classification N06AX01
IUPAC Name (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
InChI LDCYZAJDBXYCGN-VIFPVBQESA-N
Canonical SMILES N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB Wikipedia ChEMBL ZINC
Interactions with Oxitriptan
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Interactions with compound preparation
Multi-DRUG trade Multi-DRUG Drug type Warning Note