Basic Information
ID DDInter1355
Drug Type small molecule
Molecular Formula C8H14N2O4Pt
Molecular Weight 397.294
CAS Number 61825-94-3
Description Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. It is typically administered in combination with fluorouracil and leucovorin in a combination known as Folfox for the treatment of colorectal cancer. Compared to cisplatin the two amine groups are replaced by cyclohexyldiamine for improved antitumour activity. The chlorine ligands are replaced by the oxalato bidentate derived from oxalic acid in order to improve water solubility. Oxaliplatin is marketed by Sanofi-Aventis under the trademark Eloxatin®.
ATC Classification L01XA03
IUPAC Name (3aR,7aR)-octahydro-2',5'-dioxaspiro[cyclohexa[d]1,3-diaza-2-platinacyclopentane-2,1'-cyclopentane]-3',4'-dione
InChI ZROHGHOFXNOHSO-BNTLRKBRSA-L
Canonical SMILES [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider PharmGKB Therapeutic Targets Database Wikipedia ChEMBL
Interactions with Oxaliplatin
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Multi-DRUG trade Multi-DRUG Drug type Warning Note