Basic Information
ID DDInter1297
Drug Type small molecule
Molecular Formula C19H20N4O
Molecular Weight 320.396
CAS Number 1038915-60-4
Description Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells.[L43277] Niraparib is selective towards PARP-1 and PARP-2.[A253248] First approved by the FDA on March 27, 2017,[A253912] niraparib is used to treat epithelial ovarian, fallopian tube, or primary peritoneal cancer.[L43277] Niraparib was approved by the European Commission on November 16, 2017 [L43742] and by Health Canada on June 27, 2019.[L43747]
ATC Classification L01XK02
IUPAC Name 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
InChI PCHKPVIQAHNQLW-CQSZACIVSA-N
Canonical SMILES NC(=O)C1=CC=CC2=CN(N=C12)C1=CC=C(C=C1)[C@@H]1CCCNC1
Useful Links DrugBank ChEBI PubChem Substance ChemSpider BindingDB PharmGKB Wikipedia ChEMBL ZINC
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