Basic Information
ID DDInter1260
Drug Type small molecule
Molecular Formula C21H25NO3
Molecular Weight 339.435
CAS Number 55096-26-9
Description Nalmefene, a 6-methylene analogue of [naltrexone], is an opioid receptor antagonist.[L40684] It acts as an antagonist at the mu (μ)-opioid and delta (δ)-opioid receptors and a partial agonist at the kappa (κ)-opioid receptor.[L1024] In Europe, nalmefene oral tablets are used to reduce alcohol consumption in adults with alcohol dependence.[L1024] Nalmefene was approved for use in the United States in 1995 as an antidote for opioid overdose.[A245839] Nalmefene injection is used to manage known or suspected opioid overdose. It is used for complete or partial reversal of opioid drug effects, including respiratory depression, induced by either natural or synthetic opioids.[L40684]
ATC Classification N07BB05
IUPAC Name (1S,5R,13S,17S)-4-(cyclopropylmethyl)-14-methylidene-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7,9,11(18)-triene-10,17-diol
InChI WJBLNOPPDWQMCH-MBPVOVBZSA-N
Canonical SMILES OC1=CC=C2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](OC1=C24)C(=C)CC[C@@]35O
Useful Links DrugBank ChEBI KEGG Compound KEGG Drug ChemSpider BindingDB Wikipedia ChEMBL ZINC
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