Basic Information
ID DDInter1186
Drug Type small molecule
Molecular Formula C16H18ClN3S
Molecular Weight 319.850
CAS Number 61-73-4
Description Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs entered the market. Its use as an urinary tract antiseptic has also been investigated. Methylthioninium chloride (INN, or methylene blue, proposed trade name Rember) is an investigational drug being developed by the University of Aberdeen and TauRx Therapeutics that has been shown in early clinical trials to be an inhibitor of Tau protein aggregation. The drug is of potential interest for the treatment of patients with Alzheimer's disease.
ATC Classification V03AB17 V04CG05
IUPAC Name 3,7-bis(dimethylamino)-5λ⁴-phenothiazin-5-ylium chloride
InChI CXKWCBBOMKCUKX-UHFFFAOYSA-M
Canonical SMILES [Cl-].CN(C)C1=CC2=[S+]C3=C(C=CC(=C3)N(C)C)N=C2C=C1
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound ChemSpider Wikipedia ChEMBL
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