2D 3D
	ID	DDInter1165
	Drug Type	small molecule
	Molecular Formula	C8H18NO2
	Molecular Weight	160.234
	CAS Number	55-92-5
	Description	Asthma is a complex condition associated with phenomena such as airway hyperresponsiveness (AHR), in which the smooth muscle in the airways (ASM) excessively contracts in response to stimuli, reducing pulmonary function and causing symptoms such as difficulty breathing.[A229598, A229603] Although the underlying pathology of AHR is complex, ASM contraction can be stimulated by cholinergic agonists that activate M3 muscarinic receptors that stimulate ASM contraction.[A229603, A229618, A229643] Methacholine is a non-specific cholinergic agonist (parasympathomimetic) that acts through muscarinic receptors in the lungs to induce bronchoconstriction.[L31763] In patients with AHR, a lower dose of methacholine is required to induce bronchoconstriction, which forms the basis for the methacholine challenge test to diagnose AHR.[A229648, L31763] Methacholine was granted FDA approval on October 31, 1986, and is marketed under the trademark PROVOCHOLINE® by Methapharm Inc.[L31763]
	ATC Classification	V04CX03
IUPAC Name	[2-(acetyloxy)propyl]trimethylazanium
InChI	NZWOPGCLSHLLPA-UHFFFAOYSA-N
Canonical SMILES	CC(C[N+](C)(C)C)OC(C)=O
Useful Links	DrugBank ChEBI PubChem Substance KEGG Compound ChemSpider BindingDB PharmGKB Wikipedia ChEMBL