Basic Information
ID DDInter1152
Drug Type small molecule
Molecular Formula C12H14N2O2
Molecular Weight 218.252
CAS Number 50-12-4
Description Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subunit alpha. Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2B6, Cytochrome P450 1A2, and Cytochrome P450 2D6 are known to metabolize mephenytoin. Mephenytoin is a hydantoin-derivative anticonvulsant used to control various partial seizures. Mephenytoin and oxazolidinedione derivatives are associated with higher incidences of blood dyscrasias compared to other anticonvulsants.
ATC Classification N03AB04 N03AB54
IUPAC Name 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
InChI GMHKMTDVRCWUDX-UHFFFAOYSA-N
Canonical SMILES CCC1(NC(=O)N(C)C1=O)C1=CC=CC=C1
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL
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