Basic Information
ID DDInter1133
Drug Type small molecule
Molecular Formula C5H11Cl2N
Molecular Weight 156.054
CAS Number 51-75-2
Description A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCl.
ATC Classification L01AA05
IUPAC Name bis(2-chloroethyl)(methyl)amine
InChI HAWPXGHAZFHHAD-UHFFFAOYSA-N
Canonical SMILES CN(CCCl)CCCl
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
Interactions with Mechlorethamine
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Multi-DRUG trade Multi-DRUG Drug type Warning Note