Basic Information
ID DDInter1124
Drug Type small molecule
Molecular Formula C20H23N
Molecular Weight 277.403
CAS Number 10262-69-8
Description Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
ATC Classification N06AA21
IUPAC Name methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9,11,13-hexaen-1-yl}propyl)amine
InChI QSLMDECMDJKHMQ-UHFFFAOYSA-N
Canonical SMILES CNCCCC12CCC(C3=CC=CC=C13)C1=CC=CC=C21
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Guide to Pharmacology Wikipedia ChEMBL ZINC
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