2D 3D
	ID	DDInter1123
	Drug Type	small molecule
	Molecular Formula	C6H14O6
	Molecular Weight	182.172
	CAS Number	69-65-8
	Description	Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chiesi USA Inc.[L20024]
	ATC Classification	B05CX04 A06AD16 R05CB16 B05BC01 V04CX04
IUPAC Name	(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
InChI	FBPFZTCFMRRESA-KVTDHHQDSA-N
Canonical SMILES	OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Useful Links	DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC