Basic Information
ID DDInter1088
Drug Type small molecule
Molecular Formula C29H33ClN2O2
Molecular Weight 477.038
CAS Number 53179-11-6
Description Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea.[L42785] The drug was first synthesized in 1969 and used medically in 1976.[A251610] It is a highly lipophilic synthetic phenylpiperidine opioid [A251610] that is structurally similar to opiate receptor agonists such as [diphenoxylate] and [haloperidol].[A6249] Due to pharmacological properties, loperamide has been misused and abused to self-manage opioid withdrawal symptoms and to induce euphoria.[A251610, A251625] However, loperamide is associated with a risk for experiencing a range of adverse effects, often life-threatening, if taking for non-therapeutic reasons or at doses higher than the recommended dose.[L42790]
ATC Classification A07DA53 A07DA03
IUPAC Name 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
InChI RDOIQAHITMMDAJ-UHFFFAOYSA-N
Canonical SMILES CN(C)C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1=CC=CC=C1)C1=CC=CC=C1
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
Interactions with Loperamide
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Interactions with compound preparation
Multi-DRUG trade Multi-DRUG Drug type Warning Note