2D 3D
	ID	DDInter1066
	Drug Type	small molecule
	Molecular Formula	C14H22N2O
	Molecular Weight	234.337
	CAS Number	137-58-6
	Description	Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication [T583]. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures [F4349, L5930, L5948]. It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations [F4349, L5930, L5948]. In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others [F4349, L5930, L5948]. As a result, lidocaine is also considered a class Ib anti-arrhythmic agent [L5930, L5948, F4468]. Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation [A177625]. Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines [L6055].
	ATC Classification	S01HA07 D04AB01 R02AD02 C01BB01 S02DA01 N01BB52 C05AD01 N01BB02
IUPAC Name	2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
InChI	NNJVILVZKWQKPM-UHFFFAOYSA-N
Canonical SMILES	CCN(CC)CC(=O)NC1=C(C)C=CC=C1C
Useful Links	DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Guide to Pharmacology Wikipedia ChEMBL ZINC