Basic Information
ID DDInter1054
Drug Type small molecule
Molecular Formula C9H11NO4
Molecular Weight 197.188
CAS Number 59-92-7
Description Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier[Label,A177781]. Once past the blood-brain barrier, levodopa is metabolized to dopamine and supplements the low endogenous levels of dopamine to treat symptoms of Parkinson's[Label]. The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product called Sinemet that was approved on May 2, 1975[A177781,L6133].
ATC Classification N04BA03 N04BA01 N04BA02
IUPAC Name (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
InChI WTDRDQBEARUVNC-LURJTMIESA-N
Canonical SMILES N[C@@H](CC1=CC(O)=C(O)C=C1)C(O)=O
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Guide to Pharmacology Wikipedia ChEMBL ZINC
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