Basic Information
ID DDInter1045
Drug Type small molecule
Molecular Formula C20H25ClN2O5
Molecular Weight 408.880
CAS Number 103129-82-4
Description Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication.[L10833] Levamlodipine belongs to the dihydropyridine group of calcium channel blockers.[L10833] This medication was first marketed in Russia and India before being granted FDA approval.[L1484] The names S-amlodipine and levamlodipine may be used interchangeably as both substances are the same, however.[L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity.[A188940] Levamlodipine was granted FDA approval on 19 December 2019.[L10833]
ATC Classification C08CA17
IUPAC Name 3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
InChI HTIQEAQVCYTUBX-KRWDZBQOSA-N
Canonical SMILES CCOC(=O)C1=C(COCCN)NC(C)=C([C@@H]1C1=CC=CC=C1Cl)C(=O)OC
Useful Links DrugBank ChEBI PubChem Substance ChemSpider Wikipedia ChEMBL ZINC
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