Basic Information
ID DDInter1040
Drug Type small molecule
Molecular Formula C17H11N5
Molecular Weight 285.303
CAS Number 112809-51-5
Description Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine.[A190546] Letrozole was granted FDA approval on 25 July 1997.[L11623]
ATC Classification L02BG04
IUPAC Name 4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl]benzonitrile
InChI HPJKCIUCZWXJDR-UHFFFAOYSA-N
Canonical SMILES N#CC1=CC=C(C=C1)C(N1C=NC=N1)C1=CC=C(C=C1)C#N
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
Interactions with Letrozole
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Multi-DRUG trade Multi-DRUG Drug type Warning Note