Basic Information
ID DDInter1012
Drug Type small molecule
Molecular Formula C19H19NOS
Molecular Weight 309.425
CAS Number 34580-13-7
Description Ketotifen is a benzocycloheptathiophene derivative[A231204] with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and [azatadine].[A231204] Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis.[A231204] In the US, it is now used in an over-the-counter ophthalmic formulation for the treatment of itchy eyes associated with allergies,[L32278] and in Canada a prescription-only oral formulation is available and indicated as an add-on therapy for children with atopic asthma.[L32283] In addition, oral ketotifen is used in Mexico and across Europe for the treatment of various allergic symptoms and disorders,[A231204] including urticaria, mastocytosis, and food allergy.
ATC Classification S01GX08 R06AX17
IUPAC Name 2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),3(7),4,10,12-pentaen-8-one
InChI ZCVMWBYGMWKGHF-UHFFFAOYSA-N
Canonical SMILES CN1CCC(CC1)=C1C2=C(SC=C2)C(=O)CC2=CC=CC=C12
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
Interactions with Ketotifen
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Interactions with compound preparation
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